Tranexamic acid therapy in ulcerative colitis.
نویسندگان
چکیده
The antifibrinolytic drug tranexamic acid was assessed in controlling bleeding in 12 patients with left-sided proctocolitis. The study was designed as a double-blind cross-over trial employing a dose of 4-5 g of tranexamic acid/day together with identical placebo. A statistically significant reduction in rectal bleeding was achieved in 50% of cases with a minimum of side effects. Sigmoidoscopic grading of rectal mucosal appearances was improved. Frequency of diarrhoea and stool consistency were not altered. Tranexamic acid may have a part to play in the management of selected patients with ulcerative colitis in whom bleeding is difficult to control with orthodox treatment.
منابع مشابه
Thymol has beneficial effects on the experimental model of ulcerative colitis
Objective: Thymol, a natural aromatic monoterpene phenol derived from thymus, possesses anti-inflammatory benefits. Here, we evaluated the potential of thymol therapy in improving an animal model of ulcerative colitis. Materials and Methods: Luminal instillation of acetic acid was used to induce colitis in male Wistar rats. Treatment groups daily received...
متن کاملEffectiveness of Mindfulness-based Cognitive Therapy on the Perceived Stress of Patients with Ulcerative Colitis
Abstract Introduction: Various studies have shown that stress is one of the environmental factors affecting the symptoms of patients with inflammatory bowel disease. Objective: The purpose of this study was to determine the effectiveness of mindfulness-based cognitive therapy on perceived stress in patients with ulcerative colitis. Materials and Methods: This study was a quasi-experimental s...
متن کاملThe effects of crocin, mesalazine and their combination in the acetic acid-induced colitis in rats
Crocin, as a carotenoid compound of saffron, exerts a potent antioxidant property. Mesalazine is frequently used in the treatment of ulcerative colitis. This study investigated the effects of separated and combination treatments with crocin and mesalazine in a rat model of ulcerative colitis. Ulcerative colitis was induced by intra-colonic administration of acetic acid (4.00%, 1.00 mL) at 8 cm ...
متن کاملEffect of Matricaria recutita L. aqueous extract on acetic acid-induced ulcerative colitis in adult male rats
Introduction: Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms such as abdominal pain, diarrhea, and rectal bleeding. Previous studies have shown that Matricaria recutita L. have a series of physiological effects for example spasmolytic, carminative, anti...
متن کاملEffect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats
Background: The levels of IL-13, IL-4, IL-1B, TNF-α and IL-10 alter in the colon of people with ulcerative colitis. previous studies, it was found that shilajit (asphaltum) was effective in the improvement of ulcerative colitis.we guessed that the shilajit has been able to improve the ulcerative colitis by affecting the amount of cytokines. Objective: The aim of the present study was to investi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Postgraduate medical journal
دوره 58 676 شماره
صفحات -
تاریخ انتشار 1982